Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway

BACKGROUND: Mechanical ventilation (MV) used in patients with acute respiratory distress syndrome (ARDS) can cause diffuse lung inflammation, an effect termed ventilator-induced lung injury, which may produce profound pulmonary fibrogenesis. Histone deacetylases (HDACs) and serine/threonine kinase/p...

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Veröffentlicht in:PLoS One
Hauptverfasser: Li, Li-Fu, Lee, Chung-Shu, Lin, Chang-Wei, Chen, Ning-Hung, Chuang, Li-Pang, Hung, Chen-Yiu, Liu, Yung-Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325309/
https://ncbi.nlm.nih.gov/pubmed/28234968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172571
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