Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy

PURPOSE: Androgen deprivation therapy (ADT) commonly leads to incomplete cell death and the fate of persistent cells involves, in part, a senescent phenotype. Senescence is terminal growth arrest in response to cell stress that is characterized by increased lysosomal-β-galactosidase (GLB1) the origi...

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Publicado en:PLoS One
Main Authors: Blute, Michael L., Damaschke, Nathan, Wagner, Jennifer, Yang, Bing, Gleave, Martin, Fazli, Ladan, Shi, Fangfang, Abel, E. Jason, Downs, Tracy M., Huang, Wei, Jarrard, David F.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325224/
https://ncbi.nlm.nih.gov/pubmed/28234906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172048
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