Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

To examine the effects of formononetin (FMN) on Acetaminophen (APAP)-induced liver injury in vitro and in vivo. Human non-tumor hepatic cells LO2 were pretreated with either vehicle or FMN (20, 40 μM), for 6 h, followed by incubation with or without APAP (10 mM) for 24 h. In an in vivo assay, male B...

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Udgivet i:PLoS One
Main Authors: Jin, Fen, Wan, Chunpeng, Li, Weifang, Yao, Liangliang, Zhao, Hongqian, Zou, Yuan, Peng, Dewei, Huang, Weifeng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325199/
https://ncbi.nlm.nih.gov/pubmed/28234915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170900
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