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Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
We describe a systematic approach to model CHO metabolism during biopharmaceutical production across a wide range of cell culture conditions. To this end, we applied the metabolic steady state concept. We analyzed and modeled the production rates of metabolites as a function of the specific growth r...
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| Publicado no: | Biotechnol Bioeng |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5324675/ https://ncbi.nlm.nih.gov/pubmed/27869296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26214 |
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