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Copper is a Cofactor of the Formylglycine‐Generating Enzyme
Formylglycine‐generating enzyme (FGE) is an O(2)‐utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu(I) is an integral cofactor of this enzyme and binds with high affinity (K (D)=of 10(−17) m) to a pair of active‐site cysteines. These find...
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| Pubblicato in: | Chembiochem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5324649/ https://ncbi.nlm.nih.gov/pubmed/27862795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600359 |
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