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A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme
The formylglycine (FGly)-generating enzyme (FGE) uses molecular oxygen to oxidize a conserved cysteine residue in all eukaryotic sulfatases to the catalytically active FGly. Sulfatases degrade and remodel sulfate esters, and inactivity of FGE results in multiple sulfatase deficiency, a fatal disease...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1324989/ https://ncbi.nlm.nih.gov/pubmed/16368756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507592102 |
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