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A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme

The formylglycine (FGly)-generating enzyme (FGE) uses molecular oxygen to oxidize a conserved cysteine residue in all eukaryotic sulfatases to the catalytically active FGly. Sulfatases degrade and remodel sulfate esters, and inactivity of FGE results in multiple sulfatase deficiency, a fatal disease...

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Bibliografiske detaljer
Main Authors: Roeser, Dirk, Preusser-Kunze, Andrea, Schmidt, Bernhard, Gasow, Kathrin, Wittmann, Julia G., Dierks, Thomas, von Figura, Kurt, Rudolph, Markus Georg
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324989/
https://ncbi.nlm.nih.gov/pubmed/16368756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507592102
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