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Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases.
Sulfatases carry at their catalytic site a unique post-translational modification, an alpha-formylglycine residue that is essential for enzyme activity. Formylglycine is generated by oxidation of a conserved cysteine or, in some prokaryotic sulfatases, serine residue. In eukaryotes, this oxidation o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171293/ https://ncbi.nlm.nih.gov/pubmed/10205163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.8.2084 |
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