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Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data

Valid variant calling results are crucial for the use of next-generation sequencing in clinical routine. However, there are numerous variant calling tools that usually differ in algorithms, filtering strategies, recommendations and thus, also in the output. We evaluated eight open-source tools regar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Sandmann, Sarah, de Graaf, Aniek O., Karimi, Mohsen, van der Reijden, Bert A., Hellström-Lindberg, Eva, Jansen, Joop H., Dugas, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324109/
https://ncbi.nlm.nih.gov/pubmed/28233799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43169
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