Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases

Protein misfolding is a key pathological event in neurodegenerative diseases like prion diseases, synucleinopathies, and tauopathies that are collectively termed protein misfolding disorders. Prions are a prototypic model to study protein aggregation biology and therapeutic development. Attempts to...

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Publicado en:Sci Rep
Main Authors: Kondru, Naveen, Manne, Sireesha, Greenlee, Justin, West Greenlee, Heather, Anantharam, Vellareddy, Halbur, Patrick, Kanthasamy, Arthi, Kanthasamy, Anumantha
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324099/
https://ncbi.nlm.nih.gov/pubmed/28233859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43155
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