An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development

Chronic wasting disease (CWD) is a rapidly spreading prion disease of cervids, yet antemortem diagnosis, treatment, and control remain elusive. We recently developed an organotypic slice culture assay for sensitive detection of scrapie prions using ultrasensitive prion seeding. However, this model w...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kondru, Naveen, Manne, Sireesha, Kokemuller, Robyn, Greenlee, Justin, Greenlee, M. Heather West, Nichols, Tracy, Kong, Qingzhong, Anantharam, Vellareddy, Kanthasamy, Arthi, Halbur, Patrick, Kanthasamy, Anumantha G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203233/
https://ncbi.nlm.nih.gov/pubmed/32376941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64456-9
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