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An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development

Chronic wasting disease (CWD) is a rapidly spreading prion disease of cervids, yet antemortem diagnosis, treatment, and control remain elusive. We recently developed an organotypic slice culture assay for sensitive detection of scrapie prions using ultrasensitive prion seeding. However, this model w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kondru, Naveen, Manne, Sireesha, Kokemuller, Robyn, Greenlee, Justin, Greenlee, M. Heather West, Nichols, Tracy, Kong, Qingzhong, Anantharam, Vellareddy, Kanthasamy, Arthi, Halbur, Patrick, Kanthasamy, Anumantha G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203233/
https://ncbi.nlm.nih.gov/pubmed/32376941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64456-9
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