Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. GIP receptor knockout mice are protected from diet induced weight gain and thus GIP antagonists have been proposed as a treatment for obesity. In this study, we assessed t...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Shimazu-Kuwahara, Satoko, Harada, Norio, Yamane, Shunsuke, Joo, Erina, Sankoda, Akiko, Kieffer, Timothy J., Inagaki, Nobuya
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324019/
https://ncbi.nlm.nih.gov/pubmed/28271035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.01.006
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