Absence of GIP secretion alleviates age-related obesity and insulin resistance

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin secreted from enteroendocine K cells after nutrient ingestion. Fat strongly induces GIP secretion, and GIP hypersecretion is involved in high-fat diet-induced obesity and insulin resistance. Aging also induces GIP hypersecretion, but...

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Vydáno v:J Endocrinol
Hlavní autoři: Kanemaru, Yoshinori, Harada, Norio, Shimazu-Kuwahara, Satoko, Yamane, Shunsuke, Ikeguchi, Eri, Murata, Yuki, Kiyobayashi, Sakura, Hatoko, Tomonobu, Inagaki, Nobuya
Médium: Artigo
Jazyk:Inglês
Vydáno: Bioscientifica Ltd 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040458/
https://ncbi.nlm.nih.gov/pubmed/31977316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-19-0477
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