Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity

The local anaesthetics (LAs) are widely used for peripheral nerve blocks, epidural anaesthesia, spinal anaesthesia and pain management. However, exposure to LAs for long duration or at high dosage can provoke potential neuronal damages. Autophagy is an intracellular bulk degradation process for prot...

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Publicat a:J Cell Mol Med
Autors principals: Xiong, Jingwei, Kong, Qiuyue, Dai, Leyang, Ma, He, Cao, Xiaofei, Liu, Li, Ding, Zhengnian
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323818/
https://ncbi.nlm.nih.gov/pubmed/27860187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13003
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