Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants

The synthetically produced cyclic peptides solnatide (a.k.a. TIP or AP301) and its congener AP318, whose molecular structures mimic the lectin-like domain of human tumor necrosis factor (TNF), have been shown to activate the epithelial sodium channel (ENaC) in various cell- and animal-based studies....

Full description

Saved in:
Bibliographic Details
Published in:Front Pharmacol
Main Authors: Willam, Anita, Aufy, Mohammed, Tzotzos, Susan, Evanzin, Heinrich, Chytracek, Sabine, Geppert, Sabrina, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Czikora, Istvan, Lucas, Rudolf, Lemmens-Gruber, Rosa, Shabbir, Waheed
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323398/
https://ncbi.nlm.nih.gov/pubmed/28286482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00085
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items