Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants

The synthetically produced cyclic peptides solnatide (a.k.a. TIP or AP301) and its congener AP318, whose molecular structures mimic the lectin-like domain of human tumor necrosis factor (TNF), have been shown to activate the epithelial sodium channel (ENaC) in various cell- and animal-based studies....

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Willam, Anita, Aufy, Mohammed, Tzotzos, Susan, Evanzin, Heinrich, Chytracek, Sabine, Geppert, Sabrina, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Czikora, Istvan, Lucas, Rudolf, Lemmens-Gruber, Rosa, Shabbir, Waheed
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323398/
https://ncbi.nlm.nih.gov/pubmed/28286482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00085
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