Mechanism of Action of Novel Lung Edema Therapeutic AP301 by Activation of the Epithelial Sodium Channel

AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis factor lectin-like domain (TIP domain) sequence, is currently being developed as a treatment for lung edema and has been shown to reduce extravascular lung water and improve lung function in mouse, rat, and pig mo...

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Main Authors: Shabbir, Waheed, Scherbaum-Hazemi, Parastoo, Tzotzos, Susan, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Lucas, Rudolf, Lemmens-Gruber, Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834145/
https://ncbi.nlm.nih.gov/pubmed/24077967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089409
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