Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is a dynamic tumor supported by several stromal elements such as pancreatic stellate cells (PSC). Significant crosstalk exists between PSCs and tumor cells to stimulate oncogenic signaling and malignant progression of PDAC. However, how PSCs activate intercell...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nagathihalli, Nagaraj S., Castellanos, Jason A., VanSaun, Michael N., Dai, Xizi, Ambrose, Mahogany, Guo, Qiaozhi, Xiong, Yanhua, Merchant, Nipun B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323208/
https://ncbi.nlm.nih.gov/pubmed/27602757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11786
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