Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma

Pediatric high-grade glioma (HGG, WHO Grade III and IV) is a devastating brain tumor with a median survival of less than two years. PDGFRA is frequently mutated/amplified in pediatric HGG, but the significance of this finding has not been fully characterized. We hypothesize that alterations of PDGFR...

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Publicado en:Oncotarget
Autores principales: Koschmann, Carl, Zamler, Daniel, MacKay, Alan, Robinson, Dan, Wu, Yi-Mi, Doherty, Robert, Marini, Bernard, Tran, Dustin, Garton, Hugh, Muraszko, Karin, Robertson, Patricia, Leonard, Marcia, Zhao, Lili, Bixby, Dale, Peterson, Luke, Camelo-Piragua, Sandra, Jones, Chris, Mody, Rajen, Lowenstein, Pedro R., Castro, Maria G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323185/
https://ncbi.nlm.nih.gov/pubmed/27582545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11602
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