STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma

Long-term survival in patients with metastatic, relapsed, or recurrent Ewing sarcoma and rhabdomyosarcoma is dismal. Irinotecan, a topoisomerase 1 inhibitor, has activity in these sarcomas, but due to poor bioavailability of its active metabolite (SN-38) has had limited clinical efficacy. In this st...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Heske, Christine M., Mendoza, Arnulfo, Edessa, Leah D., Baumgart, Joshua T., Lee, Sunmin, Trepel, Jane, Proia, David A., Neckers, Len, Helman, Lee J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323173/
https://ncbi.nlm.nih.gov/pubmed/27608846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11869
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