CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid leukemia (AML) development and maintenance. We discovered th...

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Udgivet i:Oncotarget
Main Authors: Saint-Paul, Laetitia, Nguyen, Chi-Hung, Buffière, Anne, de Barros, Jean-Paul Pais, Hammann, Arlette, Landras-Guetta, Corinne, Filomenko, Rodolphe, Chrétien, Marie-Lorraine, Johnson, Pauline, Bastie, Jean-Noël, Delva, Laurent, Quéré, Ronan
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323116/
https://ncbi.nlm.nih.gov/pubmed/27579617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11622
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