CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid leukemia (AML) development and maintenance. We discovered th...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Saint-Paul, Laetitia, Nguyen, Chi-Hung, Buffière, Anne, de Barros, Jean-Paul Pais, Hammann, Arlette, Landras-Guetta, Corinne, Filomenko, Rodolphe, Chrétien, Marie-Lorraine, Johnson, Pauline, Bastie, Jean-Noël, Delva, Laurent, Quéré, Ronan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323116/
https://ncbi.nlm.nih.gov/pubmed/27579617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11622
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