Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells

The hematopoietic system declines with age. Myeloid-biased differentiation and increased incidence of myeloid malignancies feature aging of hematopoietic stem cells (HSCs), but the mechanisms involved remain uncertain. Here, we report that 4-mo-old mice deleted for transcription intermediary factor...

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Detaylı Bibliyografya
Asıl Yazarlar: Quéré, Ronan, Saint-Paul, Laetitia, Carmignac, Virginie, Martin, Romain Z., Chrétien, Marie-Lorraine, Largeot, Anne, Hammann, Arlette, Pais de Barros, Jean-Paul, Bastie, Jean-Noël, Delva, Laurent
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115559/
https://ncbi.nlm.nih.gov/pubmed/25002492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405546111
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