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Atomistic simulations indicate the c-subunit ring of the F(1)F(o) ATP synthase is not the mitochondrial permeability transition pore

Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the o...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Zhou, Wenchang, Marinelli, Fabrizio, Nief, Corrine, Faraldo-Gómez, José D
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323039/
https://ncbi.nlm.nih.gov/pubmed/28186490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23781
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