Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

Porcine Reproductive and Respiratory Syndrome (PRRS) is a panzootic infectious disease of pigs, causing major economic losses to the world-wide pig industry. PRRS manifests differently in pigs of all ages but primarily causes late-term abortions and stillbirths in sows and respiratory disease in pig...

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Vydáno v:PLoS Pathog
Hlavní autoři: Burkard, Christine, Lillico, Simon G., Reid, Elizabeth, Jackson, Ben, Mileham, Alan J., Ait-Ali, Tahar, Whitelaw, C. Bruce A., Archibald, Alan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322883/
https://ncbi.nlm.nih.gov/pubmed/28231264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006206
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