CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Xu, Kui, Zhou, Yanrong, Mu, Yulian, Liu, Zhiguo, Hou, Shaohua, Xiong, Yujian, Fang, Liurong, Ge, Changli, Wei, Yinghui, Zhang, Xiuling, Xu, Changjiang, Che, Jingjing, Fan, Ziyao, Xiang, Guangming, Guo, Jiankang, Shang, Haitao, Li, Hua, Xiao, Shaobo, Li, Julang, Li, Kui
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467724/
https://ncbi.nlm.nih.gov/pubmed/32876563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57132
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