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Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains
BACKGROUND: The ability to generate defined null mutations in mice revolutionized the analysis of gene function in mammals. However, gene-deficient mice generated by using 129-derived embryonic stem cells may carry large segments of 129 DNA, even when extensively backcrossed to reference strains, su...
Shranjeno v:
| izdano v: | J Thromb Haemost |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5322813/ https://ncbi.nlm.nih.gov/pubmed/27079292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13338 |
| Oznake: |
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