Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targe...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Berghe, Tom Vanden, Hulpiau, Paco, Martens, Liesbet, Vandenbroucke, Roosmarijn E., Van Wonterghem, Elien, Perry, Seth W., Bruggeman, Inge, Divert, Tatyana, Choi, Sze Men, Vuylsteke, Marnik, Shestopalov, Valery I., Libert, Claude, Vandenabeele, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800811/
https://ncbi.nlm.nih.gov/pubmed/26163370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.011
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