Transient hepatic overexpression of Insulin-like growth factor 2 induces free cholesterol and lipid droplet formation

Although insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in steatosis and steatohepatitis, a causal role of IGF2 in steatosis development remains elusive. Aim of our study was to decipher the role of IGF2 in steatosis development.Hydrodynamic gene delivery of the Igf2 plasm...

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Главные авторы: Sonja M Kessler, Stephan eLaggai, Elien evan Wonterghem, Katja eGemperlein, Rolf eMüller, Johannes eHaybaeck, Roosmarijn E Vandenbroucke, Manfred eOgris, Claude eLibert, Alexandra K Kiemer
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2016-04-01
Серии:Frontiers in Physiology
Предметы:
Fatty Liver
IGF-1
lipid droplets
NAFLD
Insulin-like growth factor 2 (Igf2)
NASH
Online-ссылка:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00147/full
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