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Total Synthesis of (−)-Spinosyn A via Carbonylative Macrolactonization

Spinosyn A (1), a complex natural product featuring a unique 5,6,5,12-fused tetracyclic core structure, is the major component of spinosad, an organic insecticide and an FDA-approved agent used worldwide. Herein, we report an efficient total synthesis of (−)-spinosyn A with 15 steps in the longest l...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Bai, Yu, Shen, Xingyu, Li, Yong, Dai, Mingji
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322741/
https://ncbi.nlm.nih.gov/pubmed/27510806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07585
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