Adipose HIF-1α Causes Obesity by Suppressing Brown Adipose Tissue Thermogenesis

Hypoxia-inducible factor-1α (HIF-1α) in adipose tissue is known to promote obesity. We hypothesized that HIF-1α interferes with brown fat thermogenesis, thus decreasing energy expenditure. To test this hypothesis, we compared transgenic mice constitutively expressing HIF-1α in adipose tissues (HIF-1...

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Publicat a:J Mol Med (Berl)
Autors principals: Jun, Jonathan C., Devera, Ronald, Unnikrishnan, Dileep, Shin, Mi-Kyung, Bevans-Fonti, Shannon, Yao, Qiaoling, Rathore, Aman, Younas, Haris, Halberg, Nils, Scherer, Philipp E., Polotsky, Vsevolod Y.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322176/
https://ncbi.nlm.nih.gov/pubmed/27738746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-016-1480-6
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