Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1 alpha (HIF-1α). Prior studies in transgenic mice have shown that HIF-1α plays a role in the metabolic dysfunction associated with obesity. Therefore, we hypothesized that, after the development of diet-indu...

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Detalhes bibliográficos
Main Authors: Shin, Mi-Kyung, Drager, Luciano F., Yao, Qiaoling, Bevans-Fonti, Shannon, Yoo, Doo-Young, Jun, Jonathan C., Aja, Susan, Bhanot, Sanjay, Polotsky, Vsevolod Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462192/
https://ncbi.nlm.nih.gov/pubmed/23049707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046562
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