MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPγS treatment

Agonist stimulation of smooth muscle is known to activate RhoA/Rho kinase signaling, and Rho kinase phosphorylates the myosin targeting subunit (MYPT1) of myosin light chain (MLC) phosphatase at Thr696 and Thr853, which inhibits the activity of MLC phosphatase to produce a Ca(2+) independent increas...

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Bibliographic Details
Published in:J Smooth Muscle Res
Main Authors: Lin, Simon, Brozovich, Frank V
Format: Artigo
Language:Inglês
Published: Japan Society of Smooth Muscle Research 2016
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Original
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321854/
https://ncbi.nlm.nih.gov/pubmed/27725371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1540/jsmr.52.66
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