Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with...

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Udgivet i:Nat Commun
Main Authors: Vermillion, Meghan S., Lei, Jun, Shabi, Yahya, Baxter, Victoria K., Crilly, Nathan P., McLane, Michael, Griffin, Diane E., Pekosz, Andrew, Klein, Sabra L., Burd, Irina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321801/
https://ncbi.nlm.nih.gov/pubmed/28220786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14575
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