Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Vermillion, Meghan S., Lei, Jun, Shabi, Yahya, Baxter, Victoria K., Crilly, Nathan P., McLane, Michael, Griffin, Diane E., Pekosz, Andrew, Klein, Sabra L., Burd, Irina
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321801/
https://ncbi.nlm.nih.gov/pubmed/28220786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14575
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