Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with...

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Pubblicato in:Nat Commun
Autori principali: Vermillion, Meghan S., Lei, Jun, Shabi, Yahya, Baxter, Victoria K., Crilly, Nathan P., McLane, Michael, Griffin, Diane E., Pekosz, Andrew, Klein, Sabra L., Burd, Irina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321801/
https://ncbi.nlm.nih.gov/pubmed/28220786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14575
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