Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing...

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Pubblicato in:Nat Commun
Autori principali: Lucanic, Mark, Plummer, W. Todd, Chen, Esteban, Harke, Jailynn, Foulger, Anna C., Onken, Brian, Coleman-Hulbert, Anna L., Dumas, Kathleen J., Guo, Suzhen, Johnson, Erik, Bhaumik, Dipa, Xue, Jian, Crist, Anna B., Presley, Michael P., Harinath, Girish, Sedore, Christine A., Chamoli, Manish, Kamat, Shaunak, Chen, Michelle K., Angeli, Suzanne, Chang, Christina, Willis, John H., Edgar, Daniel, Royal, Mary Anne, Chao, Elizabeth A., Patel, Shobhna, Garrett, Theo, Ibanez-Ventoso, Carolina, Hope, June, Kish, Jason L, Guo, Max, Lithgow, Gordon J., Driscoll, Monica, Phillips, Patrick C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321775/
https://ncbi.nlm.nih.gov/pubmed/28220799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14256
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