Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Lucanic, Mark, Plummer, W. Todd, Chen, Esteban, Harke, Jailynn, Foulger, Anna C., Onken, Brian, Coleman-Hulbert, Anna L., Dumas, Kathleen J., Guo, Suzhen, Johnson, Erik, Bhaumik, Dipa, Xue, Jian, Crist, Anna B., Presley, Michael P., Harinath, Girish, Sedore, Christine A., Chamoli, Manish, Kamat, Shaunak, Chen, Michelle K., Angeli, Suzanne, Chang, Christina, Willis, John H., Edgar, Daniel, Royal, Mary Anne, Chao, Elizabeth A., Patel, Shobhna, Garrett, Theo, Ibanez-Ventoso, Carolina, Hope, June, Kish, Jason L, Guo, Max, Lithgow, Gordon J., Driscoll, Monica, Phillips, Patrick C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2017
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321775/
https://ncbi.nlm.nih.gov/pubmed/28220799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14256
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