Membrane cholesterol access into a G-protein-coupled receptor

Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A(2A) receptor (A(2A)R) have confirmed that cholesterol finds stable bin...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Guixà-González, Ramon, Albasanz, José L., Rodriguez-Espigares, Ismael, Pastor, Manuel, Sanz, Ferran, Martí-Solano, Maria, Manna, Moutusi, Martinez-Seara, Hector, Hildebrand, Peter W., Martín, Mairena, Selent, Jana
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321766/
https://ncbi.nlm.nih.gov/pubmed/28220900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14505
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