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STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
Store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels constitute a major pathway for Ca(2+) influx and mediate many essential signalling functions in animal cells, yet how they open remains elusive. Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its activator,...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321763/ https://ncbi.nlm.nih.gov/pubmed/28220789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14512 |
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