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Mechanism of partial agonism in AMPA-type glutamate receptors
Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly—partial agonists—also exist. Whether these partial agonists have weak activity because they stabilize l...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321683/ https://ncbi.nlm.nih.gov/pubmed/28211453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14327 |
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