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Mechanism of partial agonism in AMPA-type glutamate receptors

Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly—partial agonists—also exist. Whether these partial agonists have weak activity because they stabilize l...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Salazar, Hector, Eibl, Clarissa, Chebli, Miriam, Plested, Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321683/
https://ncbi.nlm.nih.gov/pubmed/28211453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14327
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