Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expres...

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Bibliographic Details
Published in:AMB Express
Main Authors: Chen, Huixian, Mao, Ruoyu, Teng, Da, Wang, Xiumin, Hao, Ya, Feng, Xingjun, Wang, Jianhua
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321639/
https://ncbi.nlm.nih.gov/pubmed/28229435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13568-017-0345-x
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