Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity against Gram-positive bacteria. In this study, we investiga...

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Main Authors: Xiong, Yan Q., Hady, Wessam Abdel, Deslandes, Antoine, Rey, Astrid, Fraisse, Laurent, Kristensen, Hans-Henrik, Yeaman, Michael R., Bayer, Arnold S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195053/
https://ncbi.nlm.nih.gov/pubmed/21859940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00453-11
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