Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expres...

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Publicat a:AMB Express
Autors principals: Chen, Huixian, Mao, Ruoyu, Teng, Da, Wang, Xiumin, Hao, Ya, Feng, Xingjun, Wang, Jianhua
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321639/
https://ncbi.nlm.nih.gov/pubmed/28229435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13568-017-0345-x
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