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Marked Sexual Dimorphism in 5-HT(1) Receptors Mediating Pronociceptive Effects of Sumatriptan

Amongst the side effects of triptans, a substantial percentage of patients experience injection site pain and tenderness, the underlying mechanism of which is unknown. We found the dose range from 10 fg – 1000 ng (intradermal) sumatriptan induced a complex dose-dependent mechanical hyperalgesia in t...

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Pubblicato in:Neuroscience
Autori principali: Araldi, Dioneia, Ferrari, Luiz F., Green, Paul, Levine, Jon D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321636/
https://ncbi.nlm.nih.gov/pubmed/28040566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.12.031
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