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Importance of Hydrophilic Hydration and Intramolecular Interactions in the Thermodynamics of Helix–Coil Transition and Helix–Helix Assembly in a Deca-Alanine Peptide

For a model deca-alanine peptide the cavity (ideal hydrophobic) contribution to hydration favors the helix state over extended states and the paired helix bundle in the assembly of two helices. The energetic contributions of attractive protein–solvent interactions are separated into quasi-chemical c...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Tomar, Dheeraj S., Weber, Valéry, Pettitt, B. Montgomery, Asthagiri, D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321054/
https://ncbi.nlm.nih.gov/pubmed/26649757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b09881
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