Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer

PURPOSE: The primary objective was to determine safety, toxicity, and a recommended phase II dose regimen of LY2606368, an inhibitor of checkpoint kinase 1, as monotherapy. PATIENTS AND METHODS: This phase I, nonrandomized, open-label, dose-escalation trial used a 3 + 3 dose-escalation scheme and in...

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Bibliographic Details
Published in:J Clin Oncol
Main Authors: Hong, David, Infante, Jeffrey, Janku, Filip, Jones, Suzanne, Nguyen, Ly M., Burris, Howard, Naing, Aung, Bauer, Todd M., Piha-Paul, Sarina, Johnson, Faye M., Kurzrock, Razelle, Golden, Lisa, Hynes, Scott, Lin, Ji, Lin, Aimee Bence, Bendell, Johanna
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2016
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ORIGINAL REPORTS
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321045/
https://ncbi.nlm.nih.gov/pubmed/27044938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.64.5788
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