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CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice
Monogenic epilepsies with wide-ranging clinical severity have been associated with mutations in voltage-gated sodium channel genes. In the Scn2a(Q54) mouse model of epilepsy, a focal epilepsy phenotype is caused by transgenic expression of an engineered Na(V)1.2 mutation displaying enhanced persiste...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321040/ https://ncbi.nlm.nih.gov/pubmed/28137877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615774114 |
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