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Modulation of the late sodium current by Ca(2+), calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences

Augmented and slowed late Na(+) current (I(NaL)) was implicated in action potential duration variability, early afterdepolarizations, and abnormal Ca(2+) handling in human and canine failing myocardium Objective was to study I(NaL) modulation by cytosolic Ca(2+) ([Ca(2+)](i)) in normal and failing v...

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Detalhes bibliográficos
Main Authors: Maltsev, Victor A., Reznikov, Vitaliy, Undrovinas, Nidas A., Sabbah, Hani N., Undrovinas, Albertas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376056/
https://ncbi.nlm.nih.gov/pubmed/18203851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00484.2007
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