Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure

The emerging paradigm for Na(+) current in heart failure (HF) is that its transient component (I(NaT)) responsible for the action potential (AP) upstroke is decreased, whereas the late component (I(NaL)) involved in AP plateau is augmented. Here we tested whether Na(v)β(1)- and Na(v)β(2)-subunits ca...

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Bibliografiska uppgifter
Huvudupphovsmän: Mishra, Sudhish, Undrovinas, Nidas A., Maltsev, Victor A., Reznikov, Vitaliy, Sabbah, Hani N., Undrovinas, Albertas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2011
Ämnen:
Cardiac Excitation and Contraction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197374/
https://ncbi.nlm.nih.gov/pubmed/21705762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00948.2009
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