Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

TGFβ secreted by tumor stroma induces Epithelial-to-Mesenchymal Transition (EMT) in cancer cells, a reversible phenotype linked to cancer progression and drug resistance. However, exposure to stromal signals may also lead to heritable changes in cancer cells, which are poorly understood. We show tha...

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Publicat a:Cell Rep
Autors principals: Comaills, Valentine, Kabeche, Lilian, Morris, Robert, Buisson, Rémi, Yu, Min, Madden, Marissa Wells, LiCausi, Joseph A., Boukhali, Myriam, Tajima, Ken, Pan, Shiwei, Aceto, Nicola, Sil, Srinjoy, Zheng, Yu, Sundaresan, Tilak, Yae, Toshifumi, Jordan, Nicole Vincent, Miyamoto, David T., Ting, David T., Ramaswamy, Sridhar, Haas, Wilhelm, Zou, Lee, Haber, Daniel A., Maheswaran, Shyamala
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320932/
https://ncbi.nlm.nih.gov/pubmed/27926867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.022
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