Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

TGFβ secreted by tumor stroma induces Epithelial-to-Mesenchymal Transition (EMT) in cancer cells, a reversible phenotype linked to cancer progression and drug resistance. However, exposure to stromal signals may also lead to heritable changes in cancer cells, which are poorly understood. We show tha...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Comaills, Valentine, Kabeche, Lilian, Morris, Robert, Buisson, Rémi, Yu, Min, Madden, Marissa Wells, LiCausi, Joseph A., Boukhali, Myriam, Tajima, Ken, Pan, Shiwei, Aceto, Nicola, Sil, Srinjoy, Zheng, Yu, Sundaresan, Tilak, Yae, Toshifumi, Jordan, Nicole Vincent, Miyamoto, David T., Ting, David T., Ramaswamy, Sridhar, Haas, Wilhelm, Zou, Lee, Haber, Daniel A., Maheswaran, Shyamala
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320932/
https://ncbi.nlm.nih.gov/pubmed/27926867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.022
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