SETD1A protects from senescence through regulation of the mitotic gene expression program

SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic processes and consequentially, its knockdown induces senescence. SETD1A, through promoter H3K4...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Tajima, Ken, Matsuda, Satoru, Yae, Toshifumi, Drapkin, Benjamin J., Morris, Robert, Boukhali, Myriam, Niederhoffer, Kira, Comaills, Valentine, Dubash, Taronish, Nieman, Linda, Guo, Hongshan, Magnus, Neelima K. C., Dyson, Nick, Shioda, Toshihiro, Haas, Wilhelm, Haber, Daniel A., Maheswaran, Shyamala
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599037/
https://ncbi.nlm.nih.gov/pubmed/31253781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10786-w
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