SETD1A protects from senescence through regulation of the mitotic gene expression program

SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic processes and consequentially, its knockdown induces senescence. SETD1A, through promoter H3K4...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tajima, Ken, Matsuda, Satoru, Yae, Toshifumi, Drapkin, Benjamin J., Morris, Robert, Boukhali, Myriam, Niederhoffer, Kira, Comaills, Valentine, Dubash, Taronish, Nieman, Linda, Guo, Hongshan, Magnus, Neelima K. C., Dyson, Nick, Shioda, Toshihiro, Haas, Wilhelm, Haber, Daniel A., Maheswaran, Shyamala
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599037/
https://ncbi.nlm.nih.gov/pubmed/31253781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10786-w
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