Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress

Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson’s disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, we addressed the impact of aSyn specifically on mitochondrial...

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Vydáno v:Sci Rep
Hlavní autoři: Menges, Stefanie, Minakaki, Georgia, Schaefer, Patrick M., Meixner, Holger, Prots, Iryna, Schlötzer-Schrehardt, Ursula, Friedland, Kristina, Winner, Beate, Outeiro, Tiago F., Winklhofer, Konstanze F., von Arnim, Christine A. F., Xiang, Wei, Winkler, Jürgen, Klucken, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320486/
https://ncbi.nlm.nih.gov/pubmed/28224980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42942
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